US First Lady Jill Biden has tested positive for Covid-19 and developed mild symptoms, the White House said Tuesday, two weeks after her husband Joe Biden contracted the virus for a second time.

The 71-year-old wife of the president tested negative Monday but developed “cold-like symptoms late in the evening,” her communications director Elizabeth Alexander said in a statement.

A subsequent rapid antigen test was negative, but a more detailed PCR test was positive, Alexander said.

The first lady has been prescribed a course of the oral antiviral pill Paxlovid and will isolate for at least five days.

She “is double-vaccinated, twice boosted, and only experiencing mild symptoms,” Alexander added.

Jill Biden tested positive while on holiday in South Carolina, where she is staying at a private residence and will return to the White House after two consecutive negative tests, her aide said.

President Biden, who turns 80 in November, has recently recovered from two separate bouts of the coronavirus.

He first tested positive on July 21 and continued to carry out his duties while isolating at the White House.

After four days of negative tests he again received a positive result on July 30 and entered isolation a second time. (AFP)

•In the above file photo taken on June 30, 2022, First Lady Jill Biden watches as Marine One, carrying US President Joe Biden, lands on the South Lawn of the White House upon Biden’s return to Washington, DC. – First Lady Jill Biden will remain at a private residence in South Carolina after testing positive for Covid-19, according to a statement released by the First Lady’s communication director on August 16, 2022. (Photo by MANDEL NGAN / AFP)